Brentford travel to the West Midlands on Tuesday 16 January for a 19:30 kick off.
Wolves will face Brentford for the third time this season.
The bees will return to Molineux on February 10.
Coming into the game, both sides last result was the recent meeting which ended in a 1-1 draw at the Gtech Community Stadium.
Wolves come into the game with a few big names out. Following his red card in the recent game Joao Gomes will be out due to suspension. Hwang Hee-chan is unavailable for Wolves due to the attacker being on international duty in the Asian Cup.
Boubacar Traoré and Rayan Ait-Nouri are also representing their nations at the African Cup Of Nations, Jonny Otto will remain off the pitch for Wolves following his first-team ban.
Craig Dawson, Hugo Bueno and Dan Bentley all had knocks but are expected to feature.
Mario Lemina has returned to training and could be involved, following his compassionate leave.
Nathan Fraser is also expected to be in the squad.
The bees travel to Molineux without Rico Henry, Bryan Mbeumo, Kristoffer Ajer and Aaron Hickey as they are unavailable due to injury.
Yoanne Wissa and Frank Onyeka are representing their nations at AFCON.
Ivan Toney is unavailable due to his suspension, however he will return January 20.
The winner of this game will face West Bromwich Albion at The Hawthorns on January 28.
As said in my recent pre-match report for this game, one to watch for the bees will be Keane Lewis-Potter.
One to watch for Wolves in this game will be Brazilian striker Matheus Cunha.
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